Updating recipient policies for hybrid coexistence
The Helsinki Declaration suggests that trials be done in populations who are directly to use the drug, and that particular attention must be paid when trials involve vulnerable sectors such as prisoners and those of low socioeconomic status.
In principle, epidemics in a scale-free network can be quashed by identifying and immunizing just the hubs. In practice, however, hubs can be very hard to find.This sounds as if it leaves just as much to chance. In a scale-free social network - a web of friendships, say - anyone connected to another person by a friendship tie is not representative of the average. So if you know for sure that someone is part of a friendship circle, they are more likely to be a hub than is another person selected at random.In a standard mathematical model of the spread of infectious disease, the strategy of random-acquaintance immunization requires only about 50% of a population to be treated to substantially reduce the chance of an epidemic Unfortunately, the application of such vaccine cocktails can lead to the occurrence of immunodominance (ID), indicating that the immune response is limited to one epitope or a small portion of the bona fide T cell epitopes administered.The question of how many serious side-effects are acceptable to save a life has been discussed by us elsewhere.The risk-benefit equation answers the question "Is the cure (prevention) worse than the disease?